ELECTROSPUN FIBERS AND MICROSPHERES OF POLYVINYLPYRROLIDONE CONTAINING BIOACTIVE COPPER DERIVATIVE BY ELECTROSPINNING
"2022-02-21" // app/Providers/../Base/Publico/Artigo/resources/show_includes/info_artigo.blade.php
App\Base\Administrativo\Model\Artigo {#1843 // app/Providers/../Base/Publico/Artigo/resources/show_includes/info_artigo.blade.php #connection: "mysql" +table: "artigo" #primaryKey: "id" #keyType: "int" +incrementing: true #with: [] #withCount: [] +preventsLazyLoading: false #perPage: 15 +exists: true +wasRecentlyCreated: false #escapeWhenCastingToString: false #attributes: array:35 [ "id" => 83338 "edicao_id" => 195 "trabalho_id" => 57 "inscrito_id" => 157 "titulo" => "ELECTROSPUN FIBERS AND MICROSPHERES OF POLYVINYLPYRROLIDONE CONTAINING BIOACTIVE COPPER DERIVATIVE BY ELECTROSPINNING" "resumo" => "ELECTROSPINNING IS A VERSATILE TECHNOLOGY CAPABLE OF PRODUCING FIBERS, SPHERES, AND BEADS WITH MICRO OR NANOMETRIC DIAMETERS DUE TO THE ELECTROSTATIC FORCES APPLIED ON A FLUID (I.E., NORMALLY POLYMER SOLUTION). THIS LAST, IS PRODUCED BY THE ELECTROSPRAYING METHOD, WHICH IS DERIVED FROM ELECTROSPINNING TECHNOLOGY, THAT ALSO OCCURS BY ELECTROSTATIC FORCES [1]. POLYVINYLPYRROLIDONE (PVP) IS A BIODEGRADABLE, BIOCOMPATIBLE, NONTOXIC POLYMER, AND IS WIDELY USED IN THE BIOMEDICAL AREA. BESIDES, IT HAS POTENTIAL APPLICATION IN NOVEL TECHNOLOGIES AGAINST CORONAVIRUS DISEASE 2019 (COVID-19), SUCH AS PRODUCTION OF NASAL SPRAYS AND IN SITU GEL FOR DRUG RELEASE [2]. RECENTLY, A STUDY SHOWED THE COPPER SULFATE AS AN INTERESTING ANTIVIRAL [3]. IN THIS CONTEXT, WE EXPLORED THE CUSO4 €“ A COPPER DERIVATIVE, FOR INCORPORATION IN MICROSPHERES AND FIBERS OF PVP USING THE ELECTROSPINNING TECHNOLOGY WITH POSSIBILITY FUTURE TEST AGAINST SARS-COV-2. THE COPPER SULFATE (CUSO4)€“LOADED POLYVINYLPYRROLIDONE (PVP) FIBERS AND MICROSPHERES WERE SUCCESSFULLY PRODUCED BY ELECTROSPINNING. PVP/CUSO4 SOLUTIONS WITH DIFFERENT CONCENTRATIONS WERE TESTED, SUCH AS 20, 13.3, 10, AND 6.6%(W/V) OF PVP WITH 3, 1.0, 0.6, AND 0.2 % (W/V) OF CUSO4, RESPECTIVELY. WE OBSERVED CHANGE IN THE ELECTRICAL CONDUCTIVITY AND RHEOLOGICAL BEHAVIOR OF THE DIFFERENT SOLUTIONS, WHICH CONTRIBUTED TO THE FORMATION OF THE MICROSPHERES. IR SPECTRA SHOWED A CHEMICAL INTERACTION OF THE CU2+ IONS WITH OXYGEN IN THE PVP RESONANT RING. SEM IMAGES REVEALED THE MORPHOLOGY OF THE CUSO4-PVP FIBERS AND MICROSPHERES THAT EXHIBITED DIAMETERS OF 0.80 ± 0.35 µM AND 1.70 ± 0.50 µM, RESPECTIVELY. EDS MAPPING SHOWED THE PRESENCE OF COPPER IN THE ELECTROSPUN FIBERS AND MICROSPHERES MANUFACTURED. IN CONCLUSION, THE DECREASE OF THE VISCOSITY AND THE APPLICATION OF A HIGH SHEAR RATE ARE THE KEY TO INDUCING THE FORMATION OF CUSO4€“LOADED PVP MICROSPHERES, SHOWING THE ELECTROSPINNING VERSATILITY." "modalidade" => "Poster" "area_tematica" => "SPECIAL SYMPOSIUM: BIOFABRICATION" "palavra_chave" => "ELECTROSPINNING, FIBERS, MICROSPHERES, COPPER SULFATE, " "idioma" => "Português" "arquivo" => "TRABALHO_EV170_MD4_SA104_ID157_22112021184913.pdf" "created_at" => "2022-02-16 10:17:52" "updated_at" => null "ativo" => 1 "autor_nome" => "JOAO DE DEUS PEREIRA DE MORAES SEGUNDO" "autor_nome_curto" => "MORAES SEGUNDO" "autor_email" => "joaomoraessegundo@gmail.c" "autor_ies" => "FEDERAL UNIVERSITY OF CEARA" "autor_imagem" => "" "edicao_url" => "anais-do-latin-american-congress-of-artificial-organs-and-biomaterials" "edicao_nome" => "Anais do XI Latin American Congress of Artificial Organs and Biomaterials (COLAOB)" "edicao_evento" => "XI Latin American Congress of Artificial Organs and Biomaterials" "edicao_ano" => 2022 "edicao_pasta" => "anais/colaob/2021" "edicao_logo" => null "edicao_capa" => "61fc15636d9b1_03022022144819.jpg" "data_publicacao" => "2022-02-21" "edicao_publicada_em" => "2022-01-26 10:43:13" "publicacao_id" => 91 "publicacao_nome" => "Revista do Latin American Congresso of Artificial Organs and Biomaterials (COLAOB)" "publicacao_codigo" => "978-65-86901-54-2" "tipo_codigo_id" => 2 "tipo_codigo_nome" => "ISBN" "tipo_publicacao_id" => 1 "tipo_publicacao_nome" => "ANAIS de Evento" ] #original: array:35 [ "id" => 83338 "edicao_id" => 195 "trabalho_id" => 57 "inscrito_id" => 157 "titulo" => "ELECTROSPUN FIBERS AND MICROSPHERES OF POLYVINYLPYRROLIDONE CONTAINING BIOACTIVE COPPER DERIVATIVE BY ELECTROSPINNING" "resumo" => "ELECTROSPINNING IS A VERSATILE TECHNOLOGY CAPABLE OF PRODUCING FIBERS, SPHERES, AND BEADS WITH MICRO OR NANOMETRIC DIAMETERS DUE TO THE ELECTROSTATIC FORCES APPLIED ON A FLUID (I.E., NORMALLY POLYMER SOLUTION). THIS LAST, IS PRODUCED BY THE ELECTROSPRAYING METHOD, WHICH IS DERIVED FROM ELECTROSPINNING TECHNOLOGY, THAT ALSO OCCURS BY ELECTROSTATIC FORCES [1]. POLYVINYLPYRROLIDONE (PVP) IS A BIODEGRADABLE, BIOCOMPATIBLE, NONTOXIC POLYMER, AND IS WIDELY USED IN THE BIOMEDICAL AREA. BESIDES, IT HAS POTENTIAL APPLICATION IN NOVEL TECHNOLOGIES AGAINST CORONAVIRUS DISEASE 2019 (COVID-19), SUCH AS PRODUCTION OF NASAL SPRAYS AND IN SITU GEL FOR DRUG RELEASE [2]. RECENTLY, A STUDY SHOWED THE COPPER SULFATE AS AN INTERESTING ANTIVIRAL [3]. IN THIS CONTEXT, WE EXPLORED THE CUSO4 €“ A COPPER DERIVATIVE, FOR INCORPORATION IN MICROSPHERES AND FIBERS OF PVP USING THE ELECTROSPINNING TECHNOLOGY WITH POSSIBILITY FUTURE TEST AGAINST SARS-COV-2. THE COPPER SULFATE (CUSO4)€“LOADED POLYVINYLPYRROLIDONE (PVP) FIBERS AND MICROSPHERES WERE SUCCESSFULLY PRODUCED BY ELECTROSPINNING. PVP/CUSO4 SOLUTIONS WITH DIFFERENT CONCENTRATIONS WERE TESTED, SUCH AS 20, 13.3, 10, AND 6.6%(W/V) OF PVP WITH 3, 1.0, 0.6, AND 0.2 % (W/V) OF CUSO4, RESPECTIVELY. WE OBSERVED CHANGE IN THE ELECTRICAL CONDUCTIVITY AND RHEOLOGICAL BEHAVIOR OF THE DIFFERENT SOLUTIONS, WHICH CONTRIBUTED TO THE FORMATION OF THE MICROSPHERES. IR SPECTRA SHOWED A CHEMICAL INTERACTION OF THE CU2+ IONS WITH OXYGEN IN THE PVP RESONANT RING. SEM IMAGES REVEALED THE MORPHOLOGY OF THE CUSO4-PVP FIBERS AND MICROSPHERES THAT EXHIBITED DIAMETERS OF 0.80 ± 0.35 µM AND 1.70 ± 0.50 µM, RESPECTIVELY. EDS MAPPING SHOWED THE PRESENCE OF COPPER IN THE ELECTROSPUN FIBERS AND MICROSPHERES MANUFACTURED. IN CONCLUSION, THE DECREASE OF THE VISCOSITY AND THE APPLICATION OF A HIGH SHEAR RATE ARE THE KEY TO INDUCING THE FORMATION OF CUSO4€“LOADED PVP MICROSPHERES, SHOWING THE ELECTROSPINNING VERSATILITY." "modalidade" => "Poster" "area_tematica" => "SPECIAL SYMPOSIUM: BIOFABRICATION" "palavra_chave" => "ELECTROSPINNING, FIBERS, MICROSPHERES, COPPER SULFATE, " "idioma" => "Português" "arquivo" => "TRABALHO_EV170_MD4_SA104_ID157_22112021184913.pdf" "created_at" => "2022-02-16 10:17:52" "updated_at" => null "ativo" => 1 "autor_nome" => "JOAO DE DEUS PEREIRA DE MORAES SEGUNDO" "autor_nome_curto" => "MORAES SEGUNDO" "autor_email" => "joaomoraessegundo@gmail.c" "autor_ies" => "FEDERAL UNIVERSITY OF CEARA" "autor_imagem" => "" "edicao_url" => "anais-do-latin-american-congress-of-artificial-organs-and-biomaterials" "edicao_nome" => "Anais do XI Latin American Congress of Artificial Organs and Biomaterials (COLAOB)" "edicao_evento" => "XI Latin American Congress of Artificial Organs and Biomaterials" "edicao_ano" => 2022 "edicao_pasta" => "anais/colaob/2021" "edicao_logo" => null "edicao_capa" => "61fc15636d9b1_03022022144819.jpg" "data_publicacao" => "2022-02-21" "edicao_publicada_em" => "2022-01-26 10:43:13" "publicacao_id" => 91 "publicacao_nome" => "Revista do Latin American Congresso of Artificial Organs and Biomaterials (COLAOB)" "publicacao_codigo" => "978-65-86901-54-2" "tipo_codigo_id" => 2 "tipo_codigo_nome" => "ISBN" "tipo_publicacao_id" => 1 "tipo_publicacao_nome" => "ANAIS de Evento" ] #changes: [] #casts: array:14 [ "id" => "integer" "edicao_id" => "integer" "trabalho_id" => "integer" "inscrito_id" => "integer" "titulo" => "string" "resumo" => "string" "modalidade" => "string" "area_tematica" => "string" "palavra_chave" => "string" "idioma" => "string" "arquivo" => "string" "created_at" => "datetime" "updated_at" => "datetime" "ativo" => "boolean" ] #classCastCache: [] #attributeCastCache: [] #dates: [] #dateFormat: null #appends: [] #dispatchesEvents: [] #observables: [] #relations: [] #touches: [] +timestamps: false #hidden: [] #visible: [] +fillable: array:13 [ 0 => "edicao_id" 1 => "trabalho_id" 2 => "inscrito_id" 3 => "titulo" 4 => "resumo" 5 => "modalidade" 6 => "area_tematica" 7 => "palavra_chave" 8 => "idioma" 9 => "arquivo" 10 => "created_at" 11 => "updated_at" 12 => "ativo" ] #guarded: array:1 [ 0 => "*" ] }