CELL ADHESION STUDY IN BIOPOLYMERS OF DIFFERENT TOPOLOGIES OBTAINED BY ADDITIVE MANUFACTURING
"2022-02-21" // app/Providers/../Base/Publico/Artigo/resources/show_includes/info_artigo.blade.php
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STUDIES RELATED TO THE PRODUCTION OF MEDICAL EQUIPMENT BY 3D PRINTING ON BIOCOMPATIBLE POLYMERIC MATERIALS HAVE BEEN GRADUALLY GROWING, ONE OF THESE STUDIES IS BEEN CONDUCTED IN THE LABORATORY OF BIOENGINEERING AND BIOMATERIALS OF IFSP AND IT IS RELATED TO CELL ADHESION IN BIOPOLYMERS. BIOPOLYMERS HAVE A LOW MANUFACTURING COST, EASY HANDLING AND HIGH VERSATILITY IN THEIR PRODUCTION PROCESSES. ONE OF THE POSSIBLE APPLICATIONS, WHICH IS THE OBJECT OF STUDY IN THIS WORK, IS THE FABRICATION OF CASES FOR IMPLANTABLE BATTERIES USED IN MEDICAL EQUIPMENT. ASSESSING CELL ADHESION, MECHANICAL AND CHEMICAL CHARACTERISTICS OF POLYMERIC MATERIALS, CAN POINT OUT THE DIFFICULTIES PRESENTED IN 3D PRINTING VIA FUSED DEPOSITION MODELING (FDM) AND THEIR BEHAVIOR IN BIOCOMPATIBILITY TESTS FOR LATER MAKING THE CASES. THE SPECIMENS IN THE PRESENT EXPERIMENT HAVE A DIMENSION OF 10MM IN DIAMETER BY 1 MM IN THICKNESS, AS DEFINED FOR FOR CELL ADHESION WELL PLATES. FOR THE PRODUCTION OF FIRST SAMPLES, BIOPOLYMERS€™ FILAMENTS WERE USED WITH 1.75MM IN DIAMETER FOR 3D PRINTING: PCL (POLYCAPROLACTONE), ABS (ACRYLONITRILE-BUTADIENE-STYRENE) AND PLA (POLYLACTIC LACTIC ACID). THE SPECIMENS FOR CELL ADHESION TESTS WERE PRODUCED BY THE FLSUN-QQ 3D PRINTER WHOSE CHARACTERISTICS ARE COMPATIBLE WITH THE MATERIALS USED. AFTER PRINTING, THE SPECIMENS SHOWED IMPERFECTIONS OF HIGH ROUGHNESS ON THE SURFACES, VARYING FROM MATERIAL TO MATERIAL, TO OBTAIN DIFFERENT SURFACES, WERE SUBMITTED TO THE FINISHING PROCESS THROUGH THE VARIABLE SPEED SANDER POLISHER (PVV), USING STRUERS WATER SANDPAPER WITH GRAMMAGES RANGING FROM 220 AND 600. THROUGH THE TESTS, IT IS POSSIBLE TO OBSERVE THE IMPACT OF IMPERFECTIONS IN ROUGHNESS, ASSESSING THE TOPOLOGY INFLUENCE, PRESENTED IN THE ADDITIVE MANUFACTURING PROCESS WITH ITS DIFFERENT FINISHES, FOR CELL ADHESION, THUS DECIDING THE MATERIAL SELECTION FOR THE BIOPOLYMER IN THE IMPLANTABLE CASES." 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STUDIES RELATED TO THE PRODUCTION OF MEDICAL EQUIPMENT BY 3D PRINTING ON BIOCOMPATIBLE POLYMERIC MATERIALS HAVE BEEN GRADUALLY GROWING, ONE OF THESE STUDIES IS BEEN CONDUCTED IN THE LABORATORY OF BIOENGINEERING AND BIOMATERIALS OF IFSP AND IT IS RELATED TO CELL ADHESION IN BIOPOLYMERS. BIOPOLYMERS HAVE A LOW MANUFACTURING COST, EASY HANDLING AND HIGH VERSATILITY IN THEIR PRODUCTION PROCESSES. ONE OF THE POSSIBLE APPLICATIONS, WHICH IS THE OBJECT OF STUDY IN THIS WORK, IS THE FABRICATION OF CASES FOR IMPLANTABLE BATTERIES USED IN MEDICAL EQUIPMENT. ASSESSING CELL ADHESION, MECHANICAL AND CHEMICAL CHARACTERISTICS OF POLYMERIC MATERIALS, CAN POINT OUT THE DIFFICULTIES PRESENTED IN 3D PRINTING VIA FUSED DEPOSITION MODELING (FDM) AND THEIR BEHAVIOR IN BIOCOMPATIBILITY TESTS FOR LATER MAKING THE CASES. THE SPECIMENS IN THE PRESENT EXPERIMENT HAVE A DIMENSION OF 10MM IN DIAMETER BY 1 MM IN THICKNESS, AS DEFINED FOR FOR CELL ADHESION WELL PLATES. FOR THE PRODUCTION OF FIRST SAMPLES, BIOPOLYMERS€™ FILAMENTS WERE USED WITH 1.75MM IN DIAMETER FOR 3D PRINTING: PCL (POLYCAPROLACTONE), ABS (ACRYLONITRILE-BUTADIENE-STYRENE) AND PLA (POLYLACTIC LACTIC ACID). THE SPECIMENS FOR CELL ADHESION TESTS WERE PRODUCED BY THE FLSUN-QQ 3D PRINTER WHOSE CHARACTERISTICS ARE COMPATIBLE WITH THE MATERIALS USED. AFTER PRINTING, THE SPECIMENS SHOWED IMPERFECTIONS OF HIGH ROUGHNESS ON THE SURFACES, VARYING FROM MATERIAL TO MATERIAL, TO OBTAIN DIFFERENT SURFACES, WERE SUBMITTED TO THE FINISHING PROCESS THROUGH THE VARIABLE SPEED SANDER POLISHER (PVV), USING STRUERS WATER SANDPAPER WITH GRAMMAGES RANGING FROM 220 AND 600. THROUGH THE TESTS, IT IS POSSIBLE TO OBSERVE THE IMPACT OF IMPERFECTIONS IN ROUGHNESS, ASSESSING THE TOPOLOGY INFLUENCE, PRESENTED IN THE ADDITIVE MANUFACTURING PROCESS WITH ITS DIFFERENT FINISHES, FOR CELL ADHESION, THUS DECIDING THE MATERIAL SELECTION FOR THE BIOPOLYMER IN THE IMPLANTABLE CASES." 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