PLLA PRODUCED VIA DIRECT POLYCONDENSATION – AN INVESTIGATION ABOUT ITS PROCESSABILITY WITH ELECTROSPINNING
"2022-02-21" // app/Providers/../Base/Publico/Artigo/resources/show_includes/info_artigo.blade.php
App\Base\Administrativo\Model\Artigo {#1843 // app/Providers/../Base/Publico/Artigo/resources/show_includes/info_artigo.blade.php #connection: "mysql" +table: "artigo" #primaryKey: "id" #keyType: "int" +incrementing: true #with: [] #withCount: [] +preventsLazyLoading: false #perPage: 15 +exists: true +wasRecentlyCreated: false #escapeWhenCastingToString: false #attributes: array:35 [ "id" => 83321 "edicao_id" => 195 "trabalho_id" => 34 "inscrito_id" => 129 "titulo" => "PLLA PRODUCED VIA DIRECT POLYCONDENSATION – AN INVESTIGATION ABOUT ITS PROCESSABILITY WITH ELECTROSPINNING" "resumo" => "CURRENTLY, BIOMATERIALS ARE DEVELOPED AND PROCESSED FOR SPECIFIC APPLICATIONS IN THE MEDICAL FIELD. THEY CAN BE APPLIED IN PATIENTS TO COLLABORATE WITH THE REGENERATION OR EVEN THE REPLACEMENT OF ORGANS AND TISSUES, PROMOTING GREATER LONGEVITY AND QUALITY OF LIFE. FOR THIS REASON, THE INFLUENCE OF BIOMATERIALS IN THE MARKET IS EXPRESSIVE, PRESENTING A GLOBAL MARKET FORECAST THAT EXCEEDS US$ 100 BILLION (2019). BIOMATERIALS USED IN TISSUE ENGINEERING MUST ATTEND TO SOME REQUIREMENTS, SUCH AS BIOCOMPATIBILITY, HIGH POROSITY, BIODEGRADABILITY, LARGE SURFACE AREA TO VOLUME RATIO THAT FACILITATES CELLS ADHESION AND PROMOTE THEIR PROLIFERATION. AMONG THE BIOMATERIALS STUDIED, POLY(LACTIC ACID) (PLA) HAS STOOD OUT AS A BIOCOMPATIBLE POLYMER WITH GREAT BIOFUNCTIONALITY, AND EXCELLENT MECHANICAL PROPERTIES (STIFFNESS AND STRENGTH). THE FACT THAT ITS DEGRADATION PROCESS GENERATES NON-TOXIC PRODUCTS (CO2 AND H2O), COMPOUNDS PRODUCED FROM METABOLIC PROCESSES RELATED TO THE KREBS CYCLE, CONFERS ITS BIOCOMPATIBLE CHARACTERISTIC. PLA IS AN ALIPHATIC POLYESTER (POLY(HYDROXY ACIDS)) COMMONLY OBTAINED BY THE ROUTES OF DIRECT POLYCONDENSATION OR BY THE OPENING OF THE LACTIDE (CYCLIC DIMER OF LACTIC ACID). IN ADDITION, PLA IS AN ISOMER THAT CAN BE FOUND IN THREE FORMS: POLY-D-LACTIC ACID (PDLA) (RIGHT-HANDED), POLY-L-LACTIC ACID (PLLA) (LEFT-HANDED), AND POLY-D,L-LACTIC ACID (PDLLA) (MESO). THE PLLA IS LARGELY STUDIED, ITS MORE RELEVANCE IS DUE TO THE MOLECULES OF L-LACTIC ACID THAT PRODUCE POLYMERS WITH BETTER MECHANICAL PROPERTIES. GIVEN THE QUALITY OF ITS PHYSICOCHEMICAL AND MECHANICAL PROPERTIES, PLLA CAN BE PROCESSED AND ADJUSTED TO DIFFERENT CONFIGURATIONS THAT EXTEND ITS APPLICATIONS, SUCH AS IN ELECTROSPINNING. FROM THE VOLTAGE GENERATED BETWEEN A HIGH VOLTAGE SOURCE, WITH ITS POLES (POSITIVE AND NEGATIVE) RESPECTIVELY CONNECTED TO THE NEEDLE OF A SYRINGE CONTAINING THE POLYMER SOLUTION AND A GROUNDED COLLECTOR, WE CAN PRODUCE A FILM WITH FILAMENTS THAT CAN VARY FROM MICRO TO NANOMETRIC SCALE. GIVEN THIS SCENARIO, THE PRESENT WORK AIMS TO EVALUATE THE ELECTROSPINNING PROCESS OF A PLLA OBTAINED BY A DIRECT POLYCONDENSATION ROUTE. THIS POLYMER WAS CHARACTERIZED BY X-RAY DIFFRACTION (XRD) AND FOURIER TRANSFORM INFRARED SPECTROSCOPY (FTIR) TECHNIQUES. THE SCANNING ELECTRON MICROSCOPY (SEM) MICROGRAPH OF THE POLYMERIC MEMBRANE OBTAINED PRESENTED A FILM WITH SOME BEADS AND FILAMENTS BONDED. IT CAN BE RELATED TO THE SOLVENT, BECAUSE IT DID NOT REACH A SUFFICIENT TIME TO EVAPORATE, HOWEVER, IT CAN BE IMPROVED IN THE FUTURE BY INCREASING THE DISTANCE BETWEEN THE NEEDLE AND THE COLLECTOR." "modalidade" => "Poster" "area_tematica" => "NEW MATERIALS FOR BIOLOGICAL APPLICATIONS" "palavra_chave" => "DIRECT POLYCONDENSATION, PLLA, POLYMER PROCESSING, CHARACTERIZATION, " "idioma" => "Português" "arquivo" => "TRABALHO_EV170_MD4_SA_ID129_08122021104829.pdf" "created_at" => "2022-02-16 10:17:52" "updated_at" => null "ativo" => 1 "autor_nome" => "JULIANA OTAVIA BAHÚ" "autor_nome_curto" => "JU BAHÚ" "autor_email" => "juliana.bahu@gmail.com" "autor_ies" => "UNIVERSIDADE ESTADUAL DE CAMPINAS" "autor_imagem" => "" "edicao_url" => "anais-do-latin-american-congress-of-artificial-organs-and-biomaterials" "edicao_nome" => "Anais do XI Latin American Congress of Artificial Organs and Biomaterials (COLAOB)" "edicao_evento" => "XI Latin American Congress of Artificial Organs and Biomaterials" "edicao_ano" => 2022 "edicao_pasta" => "anais/colaob/2021" "edicao_logo" => null "edicao_capa" => "61fc15636d9b1_03022022144819.jpg" "data_publicacao" => "2022-02-21" "edicao_publicada_em" => "2022-01-26 10:43:13" "publicacao_id" => 91 "publicacao_nome" => "Revista do Latin American Congresso of Artificial Organs and Biomaterials (COLAOB)" "publicacao_codigo" => "978-65-86901-54-2" "tipo_codigo_id" => 2 "tipo_codigo_nome" => "ISBN" "tipo_publicacao_id" => 1 "tipo_publicacao_nome" => "ANAIS de Evento" ] #original: array:35 [ "id" => 83321 "edicao_id" => 195 "trabalho_id" => 34 "inscrito_id" => 129 "titulo" => "PLLA PRODUCED VIA DIRECT POLYCONDENSATION – AN INVESTIGATION ABOUT ITS PROCESSABILITY WITH ELECTROSPINNING" "resumo" => "CURRENTLY, BIOMATERIALS ARE DEVELOPED AND PROCESSED FOR SPECIFIC APPLICATIONS IN THE MEDICAL FIELD. THEY CAN BE APPLIED IN PATIENTS TO COLLABORATE WITH THE REGENERATION OR EVEN THE REPLACEMENT OF ORGANS AND TISSUES, PROMOTING GREATER LONGEVITY AND QUALITY OF LIFE. FOR THIS REASON, THE INFLUENCE OF BIOMATERIALS IN THE MARKET IS EXPRESSIVE, PRESENTING A GLOBAL MARKET FORECAST THAT EXCEEDS US$ 100 BILLION (2019). BIOMATERIALS USED IN TISSUE ENGINEERING MUST ATTEND TO SOME REQUIREMENTS, SUCH AS BIOCOMPATIBILITY, HIGH POROSITY, BIODEGRADABILITY, LARGE SURFACE AREA TO VOLUME RATIO THAT FACILITATES CELLS ADHESION AND PROMOTE THEIR PROLIFERATION. AMONG THE BIOMATERIALS STUDIED, POLY(LACTIC ACID) (PLA) HAS STOOD OUT AS A BIOCOMPATIBLE POLYMER WITH GREAT BIOFUNCTIONALITY, AND EXCELLENT MECHANICAL PROPERTIES (STIFFNESS AND STRENGTH). THE FACT THAT ITS DEGRADATION PROCESS GENERATES NON-TOXIC PRODUCTS (CO2 AND H2O), COMPOUNDS PRODUCED FROM METABOLIC PROCESSES RELATED TO THE KREBS CYCLE, CONFERS ITS BIOCOMPATIBLE CHARACTERISTIC. PLA IS AN ALIPHATIC POLYESTER (POLY(HYDROXY ACIDS)) COMMONLY OBTAINED BY THE ROUTES OF DIRECT POLYCONDENSATION OR BY THE OPENING OF THE LACTIDE (CYCLIC DIMER OF LACTIC ACID). IN ADDITION, PLA IS AN ISOMER THAT CAN BE FOUND IN THREE FORMS: POLY-D-LACTIC ACID (PDLA) (RIGHT-HANDED), POLY-L-LACTIC ACID (PLLA) (LEFT-HANDED), AND POLY-D,L-LACTIC ACID (PDLLA) (MESO). THE PLLA IS LARGELY STUDIED, ITS MORE RELEVANCE IS DUE TO THE MOLECULES OF L-LACTIC ACID THAT PRODUCE POLYMERS WITH BETTER MECHANICAL PROPERTIES. GIVEN THE QUALITY OF ITS PHYSICOCHEMICAL AND MECHANICAL PROPERTIES, PLLA CAN BE PROCESSED AND ADJUSTED TO DIFFERENT CONFIGURATIONS THAT EXTEND ITS APPLICATIONS, SUCH AS IN ELECTROSPINNING. FROM THE VOLTAGE GENERATED BETWEEN A HIGH VOLTAGE SOURCE, WITH ITS POLES (POSITIVE AND NEGATIVE) RESPECTIVELY CONNECTED TO THE NEEDLE OF A SYRINGE CONTAINING THE POLYMER SOLUTION AND A GROUNDED COLLECTOR, WE CAN PRODUCE A FILM WITH FILAMENTS THAT CAN VARY FROM MICRO TO NANOMETRIC SCALE. GIVEN THIS SCENARIO, THE PRESENT WORK AIMS TO EVALUATE THE ELECTROSPINNING PROCESS OF A PLLA OBTAINED BY A DIRECT POLYCONDENSATION ROUTE. THIS POLYMER WAS CHARACTERIZED BY X-RAY DIFFRACTION (XRD) AND FOURIER TRANSFORM INFRARED SPECTROSCOPY (FTIR) TECHNIQUES. THE SCANNING ELECTRON MICROSCOPY (SEM) MICROGRAPH OF THE POLYMERIC MEMBRANE OBTAINED PRESENTED A FILM WITH SOME BEADS AND FILAMENTS BONDED. IT CAN BE RELATED TO THE SOLVENT, BECAUSE IT DID NOT REACH A SUFFICIENT TIME TO EVAPORATE, HOWEVER, IT CAN BE IMPROVED IN THE FUTURE BY INCREASING THE DISTANCE BETWEEN THE NEEDLE AND THE COLLECTOR." 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