Aging is a variation of the biological process, capable of reducing the individual's adaptation to the
environment. In aging, takes place of occurrences initiated by the physiological deterioration with the
damage caused to the mitochondrial DNA. Besides the appearance of oxigen-reactive species (ROS),
produced by NADPH mitochondrial, activated by the G protein coupled receptor. The ROS can inactivate
the enzymes eNOS and MnSOD leading NF-kB. Polyphenols, secondary metabolites of plants, are correlated
with improved aging process by differents mechanisms. Thus, this review aims to characterize the action of
polyphenols on cell senescence, longevity in experimental models, as well as to identify the promoters of
lifespan (in vivo) contribute to cardiovascular system. In the present research, we describe the molecular
targets of phenolic compounds in aging cardiovascular, providing the benefits of them, since the structural
heterogeneity of the polyphenols specific arrangements, thus blocking harmful effects on the useful life,
thereby altering the structure and function of the vasculature. Quality of life is linked to the balance of agingrelated
changes, with polyphenol being one of the main cooperators for prevents cardiovascular diseases
(CVDs) in aging. In view of this, it is shown that these compounds reduce the mortality rate by guarding
senility, configuring aging prevention in prolonging cardiovascular funcion.