PLANNING, SYNTHESIS AND CHARACTERIZATION OF N-(2,4-DINITROPHENYL)HISTIDINETHIOSEMICARBAZIDES AS POTENTIAL ANTITUMOUR AGENTS
Autor(es): EVERTON FIDELIS DO NASCIMENTO e orientado por JOSÉ MAURÍCIO DOS SANTOS FILHO
The planning, synthesis and antitumoral evaluation of Nα-(2,4-dinitrophenyl)-histidinethiosemicarbazide have been one field of research effort at the SintMed®. Exploiting the association between an amino acid scaffold and the thiosemicarbazide moiety, a new series of compounds was designed, and synthesised in order to investigate their biological activity. Once amino acids are a structural leitmotiv in the evolution, their incorporation in synthetic compounds represents a promising strategy toward the development of new antitumour drugs. A library of histidinethiosemicarbazide derivatives was prepared, and characterised through spectroscopic methods. Their biological activity are now under investigation, and the initial perspectives point to positive outcomes.
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