Resumo Trabalho

EFFECTS OF POLYPHENOLS ON CARDIOVASCULAR AGING

ANDREYNA RAQUEL PEREIRA NASCIMENTO, GABRIELA DA SILVA NASCIMENTO, JOILSA FERNANDA CANDIDO DOS SANTOS, FRANCIELY OLIVEIRA DE LIMA e orientado por THAÍS PORTO RIBEIRO e orientado por THAÍS PORTO RIBEIRO

Aging is a variation of the biological process, capable of reducing the individual's adaptation to the environment. In aging, takes place of occurrences initiated by the physiological deterioration with the damage caused to the mitochondrial DNA. Besides the appearance of oxigen-reactive species (ROS), produced by NADPH mitochondrial, activated by the G protein coupled receptor. The ROS can inactivate the enzymes eNOS and MnSOD leading NF-kB. Polyphenols, secondary metabolites of plants, are correlated with improved aging process by differents mechanisms. Thus, this review aims to characterize the action of polyphenols on cell senescence, longevity in experimental models, as well as to identify the promoters of lifespan (in vivo) contribute to cardiovascular system. In the present research, we describe the molecular targets of phenolic compounds in aging cardiovascular, providing the benefits of them, since the structural heterogeneity of the polyphenols specific arrangements, thus blocking harmful effects on the useful life, thereby altering the structure and function of the vasculature. Quality of life is linked to the balance of agingrelated changes, with polyphenol being one of the main cooperators for prevents cardiovascular diseases (CVDs) in aging. In view of this, it is shown that these compounds reduce the mortality rate by guarding senility, configuring aging prevention in prolonging cardiovascular funcion.

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